Die Preisträger*innen der Wissenschaftspreise

Die GlaxoSmithKline Stiftung vergibt jährlich zwei Preise für die biomedizinische Forschung: für die Grundlagenforschung seit 1988 und für die klinische Forschung seit 1989.

Auszeichnungen im Überblick

Medizinische Grundlagenforschung

  • 2022

    Dr. Sarah Kim-Hellmuth

    The impact of sex on gene expression and its genetic regulation across human tissues.

  • 2021

    Dr. Konstantin Sparrer

    Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.

  • 2020

    Prof. Dr. Dominic Grün

    Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors.

  • 2019

    Dr. Luise Erpenbeck

    Chromatin swelling drives neutrophil extracellular trap release.

  • 2018

    Dr. Sebastian Theurich

    IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis.

  • 2017

    Prof. Dr. Oliver Söhnlein

    Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.

  • 2016

    Dr. Markus Landthaler

    A Variety of Dicer Substrates in Human and C. elegans. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kB pathway.

  • 2015

    Dr. Andrew Pospisilik

    Paternal diet defines offspring chromatin state and intergenerational obesity. Heme Oxygenase-1 Drives Metaflammatoin and Insulin Resistance in Mouse and Man.

  • Dr. Simon Fillatreau

    IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.

  • 2014

    Dr. Andrea Ablasser

    Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

  • 2013

    Dr. Marisa Karow

    Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells.

  • 2012

    Prof. Dr. H. C. Reinhardt

    DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization.

  • 2011

    Dr. Daniel N. Wilson

    Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition. Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.

  • 2010

    Prof. Dr. Veit Hornung

    RIG-I-dependent sensing of poly (dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.

  • 2009

    Prof. Dr. Norbert Hübner

    Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.

  • 2008

    Prof. Dr. Bernhard Nieswandt

    An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation and thrombus formation in vitro and in vivo.

  • 2007

    PD Dr. Volker Heussler

    Manipulation of Host Hepatocytes by the Malaria parasite for Delivery into Liver Sinusoids.

  • 2006

    Dr. Ann-Kristin Müller

    Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface.

  • Prof. Dr. Ivan Dikic

    Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Ubiquitin-binding domains in Y-family polymerases regulate translesion Synthesis.

  • 2005

    PD Dr. med. Karl Rudolph

    Telomere length is reset during early mammalian embryogenesis. Mitogen Stimulation Cooperates with Telomere Shortening To Activate DNA Damage Responses and Senescene Signaling.

  • 2004

    Dr. Michael Zeisberg

    BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models.

  • Dr. Kirsten Lauber

    Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal.

  • 2003

    Prof. Dr. Christian Weber

    Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes.

  • 2002

    Prof. Dr. Patrick Cramer

    Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution.

  • 2001

    PD Dr. Elke Roeb

    An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist.

  • 2000

    Dr. habil. Thomas Willnow

    An Endocytic Pathway for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3.

  • 1999

    Prof. Dr. Richard Kroczek

    CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells.

  • PD Dr. Rita Gerardy-Schahn

    Die Bedeutung der Polysialinsäure für das Wachstum und Metastasierungsverhalten neuroendokriner und lymphoider Tumoren.

  • PD Dr. Ortrud Steinlein

    A Potassium Channel Mutation in Neonatal Human Epilepsy.

  • 1998

    Dr. Stefan Offermanns

    Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency.

  • 1997

    Prof. Dr. Dr. Manfred W. Kiliman

    Mutations in the testis/liver isoform of the phosphoylase kinase γ subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat and in humans.

  • 1996

    Prof. Dr. Dietmar Vestweber

    The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor.

  • 1995

    Dr. Ludwig Thierfelder

    A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.

  • 1994

    Prof. Dr. Martin Krönke

    Human 55-kDa receptor for tumor necrosis factor couples to signal transduction cascades.

  • 1993

    PD Dr. Peter Gierschik

    sozyme-selective stimulation of phospholipase C-β2 by G-protein βγ-subunits.

  • 1992

    PD Dr. Klaus Ley

    Endothelial, not hemodynamic differences are responsible for preferential leukocyte rolling in rat mesenteric venules.

  • 1991

    Prof. Dr. Stefan H. E. Kaufmann

    T-Cells against a bacterial heat shock protein recognize stressed macrophages.

  • 1990

    Prof. Dr. Bernhard Fleischer

    Stimulation von T-Lymphozyten durch mikrobielle Exotoxine: Ein in der Evolution konservierter Mechanismus.

  • 1989

    Prof. Dr. Peter C. Weber PD; Dr. Sven Fischer; Dr. Clemens von Schacky

    zelluläre Funktionen.

  • 1988

    Prof. Dr. Wolfram H. Gerlich; Dr. Klaus-Hinrich Heermann

    Wege zu einem optimalen Impfstoff gegen Hepatitis-B-Viren.

  • Prof. Dr. Karl-G. Dorst

    Entwicklung und Erprobung eines integrativen Behandlungsprogramms bei essentieller Hypertonie.

Klinische Forschung

  • 2022

    PD Dr. Dr. Sebastian Zundler

    Residual homing of α4β7-expressing β1 + PI16 + regulatory T cells with potent suppressive activity correlates with exposure-efficacy of vedolizumab.

  • 2021

    Dr. Kilian Schober

    Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection.

  • 2020

    Dr. Sophie Duraffour

    Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak.

  • 2019

    Dr. Stephanie Stanelle-Bertram

    Male offspring born to mildly ZIKV-infected Mice are at risk to develop neurocognitive disorders in adulthood.

  • 2018

    Professor Dr. Volker Rudolph

    Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodelling.

  • 2017

    Dr. Nikolaus Wenger

    Spatiotemporal neuromodulation strategies engaging muscle synergies improve motor control after spinal cord injury.

  • 2016

    Dr. Dr. Marc Aurel Busche

    Rescue of long-range circuit dysfunction in Alzheimer’s disease models. Decreased amyloid-ß and increased neuronal hyperactivity by immunotherapy in Alzheimer’s models.

  • 2014

    Prof. Dr. Roman Thomas

    Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. A Genomics-Based Classification of Human Lung Tumors.

  • 2013

    Dr. Manuel Friese

    TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

  • 2012

    Dr. Jürgen Schauber

    Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions.

  • 2011

    Prof. Dr. Eicke Latz

    NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.

  • 2010

    Prof. Dr. Stefanie Dimmeler; Dr. Angelika Bonauer

    MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice.

  • 2009

    PD Dr. Reinhard Voll

    Induction of inflammatory and immune responses by HMGB1-nucleosome complexes – implications for the immunopathogenesis of SLE. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.

  • 2008

    Prof. Dr. Frank Kirchhoff; Dr. Jan Münch

    Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection.

  • 2007

    Prof. Dr. Christoph Klein

    Deficiency of HAX1 causes autosomal recessive severe congenital neutropenia (Kostmann disease) – A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.

  • PD Dr. Bruno Scheller

    Behandlung der Restenose durch Kurzzeitapplikation von Paclitaxel: von der Zellkultur zum beschichteten Ballonkatheter.

  • 2006

    Dr. Stephan E. L. Lehnart; Dr. Xander H. T. Wehrens

    Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias.

  • 2005

    PD Dr. Ulrich E. Schaible

    Saposin C is required for lipid presentation by human CD1b. Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells.

  • 2004

    Dr. Max S. Topp

    Restoration of CD28 Expression in CD28- CD8+ Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production.

  • PD Dr. Stefan Kubicka

    Involvement of TRAIL and its receptors in viral hepatitis. Caspase 8 small interfering RNA prevents acute liver failure in mice.

  • 2003

    Prof. Dr. Wolf-Henning Boehncke

    Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model. Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation.

  • PD Dr. Michael P. Schön; Dr. Margarete Schön

    Tumor-selective induction of apoptosis by the small-molecule immune response modifier imiquimod.

  • 2002

    PD Dr. Steffen Stenger

    Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors. T-cell release of granulysin contributes to host defense in leprosy.

  • Dr. Stephan Ludwig; Dr. Stephan Pleschka

    Influenza Virus-induced AP-1-dependent Gene Expression Requires Activation of the JNK Signaling Pathway. Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade.

  • 2001

    Dr. Young-Ae Lee

    A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.

  • 2000

    Dr. Christian Körner

    Carbohydrate deficient glycoprotein syndrome type IV.

  • 1998

    PD Dr. Michael Hallek

    Molekulare Pathogenese der chronischen myeloischen Leukämie.

  • 1997

    Prof. Dr. Klaus-Michael Debatin

    Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug induced apoptosis in leukemia cells.

  • 1996

    Prof. Dr. Herta Flor

    Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation.

  • 1995

    Prof. Dr. Ulrich Walter

    cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.

  • 1993

    PD Dr. Erik C. Böttger

    Disseminated mycobacterium genavense infection in patients with AIDS.

  • 1992

    Prod. Dr. Erland Erdmann; Dr. Michael Böhm; Dr. Robert H.G. Schwinger

    Die Herzinsuffizienz des Menschen als Regulationsstörung der Kontraktionskraft durch Veränderung der cAMP-Bildung und der Calciumhomöostase.

  • 1991

    Prof. Dr. Reinhard Kandolf

    A search for the enteroviral capsid protein VP 1 in pancreases of patients with Type 1 (insulin-dependent) diabetes and pancreases of hearts of infants who died of coxsackieviral myocarditis.

  • 1990

    Prof. Dr. Michael P. Manns

    Die LKM-Antikörper-positive chronisch aktive Hepatitis- eine Autoimmunkrankheit mit Modellcharakter.

  • 1989

    Prof. Dr. Walter Brendel; Dr. Michael Delius; Dr. Joseph Holl; Prof. Dr. Gustav Paumgartner; Dr. Michael Sackmann; Prof. Dr. Tilman Sauerbruch

    Einführung der extrakorporalen Stoßwellenlithotripsie (ESWL) in die Gastroenterologie.