The impact of sex on gene expression and its genetic regulation across human tissues.
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors.
Chromatin swelling drives neutrophil extracellular trap release.
IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis.
Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
A Variety of Dicer Substrates in Human and C. elegans. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kB pathway.
Paternal diet defines offspring chromatin state and intergenerational obesity. Heme Oxygenase-1 Drives Metaflammatoin and Insulin Resistance in Mouse and Man.
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells.
DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization.
Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition. Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.
RIG-I-dependent sensing of poly (dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation and thrombus formation in vitro and in vivo.
Manipulation of Host Hepatocytes by the Malaria parasite for Delivery into Liver Sinusoids.
Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface.
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Ubiquitin-binding domains in Y-family polymerases regulate translesion Synthesis.
Telomere length is reset during early mammalian embryogenesis. Mitogen Stimulation Cooperates with Telomere Shortening To Activate DNA Damage Responses and Senescene Signaling.
BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models.
Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal.
Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes.
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution.
An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist.
An Endocytic Pathway for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3.
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells.
Die Bedeutung der Polysialinsäure für das Wachstum und Metastasierungsverhalten neuroendokriner und lymphoider Tumoren.
A Potassium Channel Mutation in Neonatal Human Epilepsy.
Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency.
Mutations in the testis/liver isoform of the phosphoylase kinase γ subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat and in humans.
The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor.
A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.
Human 55-kDa receptor for tumor necrosis factor couples to signal transduction cascades.
sozyme-selective stimulation of phospholipase C-β2 by G-protein βγ-subunits.
Endothelial, not hemodynamic differences are responsible for preferential leukocyte rolling in rat mesenteric venules.
T-Cells against a bacterial heat shock protein recognize stressed macrophages.
Stimulation von T-Lymphozyten durch mikrobielle Exotoxine: Ein in der Evolution konservierter Mechanismus.
zelluläre Funktionen.
Wege zu einem optimalen Impfstoff gegen Hepatitis-B-Viren.
Entwicklung und Erprobung eines integrativen Behandlungsprogramms bei essentieller Hypertonie.
Residual homing of α4β7-expressing β1 + PI16 + regulatory T cells with potent suppressive activity correlates with exposure-efficacy of vedolizumab.
Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection.
Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak.
Male offspring born to mildly ZIKV-infected Mice are at risk to develop neurocognitive disorders in adulthood.
Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodelling.
Spatiotemporal neuromodulation strategies engaging muscle synergies improve motor control after spinal cord injury.
Rescue of long-range circuit dysfunction in Alzheimer’s disease models. Decreased amyloid-ß and increased neuronal hyperactivity by immunotherapy in Alzheimer’s models.
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. A Genomics-Based Classification of Human Lung Tumors.
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions.
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice.
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes – implications for the immunopathogenesis of SLE. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.
Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection.
Deficiency of HAX1 causes autosomal recessive severe congenital neutropenia (Kostmann disease) – A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.
Behandlung der Restenose durch Kurzzeitapplikation von Paclitaxel: von der Zellkultur zum beschichteten Ballonkatheter.
Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias.
Saposin C is required for lipid presentation by human CD1b. Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells.
Restoration of CD28 Expression in CD28- CD8+ Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production.
Involvement of TRAIL and its receptors in viral hepatitis. Caspase 8 small interfering RNA prevents acute liver failure in mice.
Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model. Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation.
Tumor-selective induction of apoptosis by the small-molecule immune response modifier imiquimod.
Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors. T-cell release of granulysin contributes to host defense in leprosy.
Influenza Virus-induced AP-1-dependent Gene Expression Requires Activation of the JNK Signaling Pathway. Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade.
A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.
Carbohydrate deficient glycoprotein syndrome type IV.
Molekulare Pathogenese der chronischen myeloischen Leukämie.
Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug induced apoptosis in leukemia cells.
Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation.
cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.
Disseminated mycobacterium genavense infection in patients with AIDS.
Die Herzinsuffizienz des Menschen als Regulationsstörung der Kontraktionskraft durch Veränderung der cAMP-Bildung und der Calciumhomöostase.
A search for the enteroviral capsid protein VP 1 in pancreases of patients with Type 1 (insulin-dependent) diabetes and pancreases of hearts of infants who died of coxsackieviral myocarditis.
Die LKM-Antikörper-positive chronisch aktive Hepatitis- eine Autoimmunkrankheit mit Modellcharakter.
Einführung der extrakorporalen Stoßwellenlithotripsie (ESWL) in die Gastroenterologie.
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Kontakt
Dagmar Weis
T. +49 89 744200-450
info@gsk-stiftung.de
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