Medizinische Grundlagenforschung

Preisträger Medizinische Grundlagenforschung 1988 – 2019

 

2019	Dr. Luise Erpenbeck	Chromatin swelling drives neutrophil extracellular trap release.
2018	Dr. Sebastian Theurich	IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis.
2017	Prof. Dr. Oliver Söhnlein	Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
2016	Dr. Markus Landthaler	A Variety of Dicer Substrates in Human and C. elegans. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kB pathway.
2015	Dr. Andrew Pospisilik	Paternal diet defines offspring chromatin state and intergenerational obesity. Heme Oxygenase-1 Drives Metaflammatoin and Insulin Resistance in Mouse and Man.
	Dr. Simon Fillatreau	IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.
2014	Dr. Andrea Ablasser	Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
2013	Dr. Marisa Karow	Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells.
2012	Prof. Dr. H. C. Reinhardt	DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization.
2011	Dr. Daniel N. Wilson	Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition. Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.
2010	Prof. Dr. Veit Hornung	RIG-I-dependent sensing of poly (dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
2009	Prof. Dr. Norbert Hübner	Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
2008	Prof. Dr. Bernhard Nieswandt	An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation and thrombus formation in vitro and in vivo.
2007	PD Dr. Volker Heussler	Manipulation of Host Hepatocytes by the Malaria parasite for Delivery into Liver Sinusoids.
2006	Dr. Ann-Kristin Müller	Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface.
	Prof. Dr. Ivan Dikic	Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Ubiquitin-binding domains in Y-family polymerases regulate translesion Synthesis.
2005	PD Dr. med. Karl Rudolph	Telomere length is reset during early mammalian embryogenesis. Mitogen Stimulation Cooperates with Telomere Shortening To Activate DNA Damage Responses and Senescene Signaling.
2004	Dr. Michael Zeisberg	BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models.
	Dr. Kirsten Lauber	Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal.
2003	Prof. Dr. Christian Weber	Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes.
2002	Prof. Dr. Patrick Cramer	Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution.
2001	PD Dr. Elke Roeb	An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist.
2000	Dr. habil. Thomas Willnow	An Endocytic Pathway for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3.
1999	Prof. Dr. Richard Kroczek	CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells.
	PD Dr. Rita Gerardy-Schahn	Die Bedeutung der Polysialinsäure für das Wachstum und Metastasierungsverhalten neuroendokriner und lymphoider Tumoren.
	PD Dr. Ortrud Steinlein	A Potassium Channel Mutation in Neonatal Human Epilepsy.
1998	Dr. Stefan Offermanns	Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency.
1997	Prof. Dr. Dr. Manfred W. Kiliman	Mutations in the testis/liver isoform of the phosphoylase kinase γ subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat and in humans.
1996	Prof. Dr. Dietmar Vestweber	The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor.
1995	Dr. Ludwig Thierfelder	A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.
1994	Prof. Dr. Martin Krönke	Human 55-kDa receptor for tumor necrosis factor couples to signal transduction cascades.
1993	PD Dr. Peter Gierschik	sozyme-selective stimulation of phospholipase C-β2 by G-protein βγ-subunits.
1992	PD Dr. Klaus Ley	Endothelial, not hemodynamic differences are responsible for preferential leukocyte rolling in rat mesenteric venules.
1991	Prof. Dr. Stefan H. E. Kaufmann	T-Cells against a bacterial heat shock protein recognize stressed macrophages.
1990	Prof. Dr. Bernhard Fleischer	Stimulation von T-Lymphozyten durch mikrobielle Exotoxine: Ein in der Evolution konservierter Mechanismus.
1989	Prof. Dr. Peter C. Weber PD Dr. Sven Fischer Dr. Clemens von Schacky	zelluläre Funktionen.
1988	Prof. Dr. Wolfram H. Gerlich Dr. Klaus-Hinrich Heermann	Wege zu einem optimalen Impfstoff gegen Hepatitis-B-Viren.
	Prof. Dr. Karl-G. Dorst	Entwicklung und Erprobung eines integrativen Behandlungsprogramms bei essentieller Hypertonie.